Project results - a selection
Method development / new protocols / software products:
- NGS and high-throughput fragment analysis techniques (MLVA) for zoonotic pathogens PBA-Zoo
- DNA / RNA isolation from rodent tissues
- Establishment of the pyrosequencing method for testing cerebrospinal fluid samples for infectious agents in unexplained human meningitis
- Further development of Luminex technology for the detection of toxins in food and biosamples (development using the example of botulinum neurotoxin (BoNT))
- Modeling method / modeling tool to identify potential risk areas for zoonoses, taking into account current climate and other research data; vulnerability analysis [Zoonose-RISKTOOL 2]
- Establishment of siRNA knock-out on primary avian macrophages to study host-pathogen interaction; protocols for isolation and transfection of macrophage siRNA KnockDown
- Simulation software for epidemic models using influenza as an example
- Modern listeria typing for outbreak investigation
Biobanks / pathogen banks / databases
- Rodent biobank (feces, intestine, pinna, liver, kidney, spleen, transudate, incl. biometric data)
- Rodent pathogen database (isolated pathogens are decentralized)
- Biobank on organs and secretions and excretions of wild deer in Bavaria
- Giardia biobank (human and animal isolates)
- Isolate bank of C. difficile, isolated from dogs, cats and humans
- Fecal samples (dog, cat, human) [In addition to the samples from the Clostridium difficile project, there are also fecal and stool samples from a Giardia project].
- MALDI-TOF database for the identification of Arcobacter
- Arcobacter strain and data collection incl. characterization of the strains
- Standardized test material from squirrels (tissue samples and swab samples)
Libraries
- Antibody library for the identification of glycolipid receptors
- Complete mutant bank for cowpox viruses
- Antigen bank of thogotoviruses as a diagnostic tool
- Lectin library from human, mosquito and sheep for binding studies with viral glycoprotein
In vitro and in vivo models
- Red-backed vole model for research into zoonoses in wild rodents
- Human liver cell model for the investigation of liver diseases
- Mosquito cell model for the isolation of arboviruses
- Respiratory tract and kidney epithelial cell model from rodents and insectivores for research into zoonoses without animal testing
- Skin model (expected from 2017) for research into skin mycoses and parasitoses
- Squirrel animal model [ - expected from 2017 - ]
- Characterized squirrel cell lines
Maps and atlases
- Risk map for hantaviruses and other rodent-associated zoonoses in Baden-Württemberg based on rodent and environmental data
- Risk maps for predicting the spread of emerging zoonoses
- Model of risk maps with spatial and temporal analysis of regions in relation to specific vectors or pathogens
- Tick atlas (from 2017)